There must have been children who thought of Hostess Twinkies ads as canon. "My favourite Daredevil adventure is the one where he gets into a fight with a guy who thought he'd said he smelled of socks."
Funny you should say it, because there is actually some evidence that, at least at Marvel anyway, the Twinkie ads ARE canon. In the story arc of THUNDERBOLTS where the Crimson Cowl's enormous Masters of Evil are revealed, one of the members of this villain group was Icemaster.
Icemaster's only previous appearance? Fighting the Human Torch in a Hostess cupcake ad, sporting such winning dialogue as:
"What CRUST! So LIGHT, so TENDER! And I'm really...WARMING...up to the fruit filling!"